SKU: A60725-050-EP
RSPO3 Polyclonal Antibody, HRP Conjugated
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | ELISA |
| Label | HRP |
| Synonyms | R-spondin-3, RSPO3, PWTSR, THSD2, Protein with TSP type-1 repeat, hPWTSR, Roof plate-specific spondin-3, hRspo3, Thrombospondin type-1 domain-containing protein 2 |
| UniProt ID | Q9BXY4 |
| Immunogen | Recombinant Human R-spondin-3 protein (22-272AA) |
| Background | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
A60725-050-EP
Name
RSPO3 Polyclonal Antibody, HRP Conjugated
Price(50 ul)
Pack Size