SKU: A55088-100-EP
RNASEL Polyclonal Antibody, FITC Conjugated
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | ELISA |
| Label | FITC |
| Synonyms | 2-5A-dependent RNase, Ribonuclease 4, Ribonuclease L, RNase L, RNASEL, RNS4 |
| UniProt ID | Q05823 |
| Immunogen | Recombinant Human 2-5A-dependent ribonuclease protein (330-741AA) |
| Background | Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
A55088-100-EP
Name
RNASEL Polyclonal Antibody, FITC Conjugated
Price(10000 ul)
Pack Size