SKU: AN300264P-100ul-ELS
Recombinant TSPAN1 Monoclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | Immunohistochemistry, Flow Cytometry |
| Label | Unconjugated |
| Synonyms | NET, TSPAN, TM4C, TM4SF, NET1, TSPAN1 |
| UniProt ID | O60635 |
| Immunogen | Recombinant Human TSPAN1 Protein |
| Background | TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-8 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone; in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Clone Name | 11B6 |
| Buffer | 0.2 μm filtered solution in PBS |
| Clonality | Monoclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
AN300264P-100ul-ELS
Name
Recombinant TSPAN1 Monoclonal Antibody
Price(100 ul)
Pack Size
100 ul