SKU: AN301767L-100ul-ELS
Recombinant Topoisomerase I Monoclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Rat, Mouse |
| Application | Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, Immunoprecipitation |
| Label | Unconjugated |
| Synonyms | TOP,TOP1,TOPI |
| Gene ID | 7150 |
| UniProt ID | P11387 |
| Immunogen | Recombinant human Topoisomerase I fragment |
| Background | DNA topoisomerases play essential roles in many DNA metabolic processes including DNA repair. Topoisomerases can introduce DNA damage upon exposure to drugs that stabilize the covalent protein-DNA intermediate of the topoisomerase reaction. Lesions in DNA are also able to trap topoisomerase-DNA intermediates. DNA topoisomerase I (Top1) catalyzes the relaxation of supercoiled DNA by a mechanism of transient DNA strand cleavage characterized by the formation of a phosphotyrosyl bond between the DNA end and active site tyrosine. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG, κ |
| Concentration | 1 mg/mL |
| Clone Name | A475 |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Clonality | Monoclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
AN301767L-100ul-ELS
Name
Recombinant Topoisomerase I Monoclonal Antibody
Price(100 ul)
Pack Size