SKU: AN300469P-100ul-ELS
Recombinant ASGPR1/ASGR1 Monoclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Mouse |
| Application | IHC-P |
| Label | Unconjugated |
| Synonyms | Asgr-1, Asgr1, ASGPR1, Asgr, HL-1 |
| UniProt ID | P34927 |
| Immunogen | Recombinant Mouse ASGPR1/ASGR1 protein |
| Background | The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Clone Name | 9B10 |
| Buffer | 0.2 μm filtered solution in PBS |
| Clonality | Monoclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
AN300469P-100ul-ELS
Name
Recombinant ASGPR1/ASGR1 Monoclonal Antibody
Price(100 ul)
Pack Size