SKU: E-AB-F1021A-100mg-ELS
Purified Anti-Mouse CD22 Antibody[Cy34.1]
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Mouse |
| Application | FCM |
| Label | Unconjugated |
| Synonyms | B-cell receptor CD22, Cd22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, CD22, Lyb-8, Siglec2, |
| Gene ID | 12483 |
| UniProt ID | P35329 |
| Background | The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig μ chain are augmented in the presence of Cy34.1 mAb. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1, κ |
| Concentration | ≥1 mg/mL |
| Clone Name | Cy34.1 |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
PDF
Datasheet
Catalog Number
E-AB-F1021A-100mg-ELS
Name
Purified Anti-Mouse CD22 Antibody[Cy34.1]
Price(100 mg)
Pack Size