SKU: AN007780P-100mg-ELS
Purified Anti-Human CD268 Antibody[H353-4A2]
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | FCM |
| Label | Unconjugated |
| Synonyms | CVID, TNFRSF13C, BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin, BAFF R, Tumor Necrosis Factor Receptor Superfamily Member 13C, BR3, BR3, TNFRSF13c, B cell activating factor receptor, BAFF receptor, BAFF receptor (BAFF-R), B-cell-activating factor receptor, BLyS receptor 3, BlySR3, BR 3, CD 268, CD268 antigen, MGC138235, OTTHUMP00000028746, TNFRSF 13C, TR13C, Tumor necrosis factor receptor subunit member 13C |
| UniProt ID | Q96RJ3 |
| Immunogen | Recombinant Human CD268 protein |
| Background | B-cell activating factor (BAFF), also known as BlyS, TALL-1, TNAK, and zTNF4, is a TNF ligand superfamily member and has been designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell matuRation. BAFF binds to three TNF receptor superfamily members: B-cell matuRation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a prolifeRation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and Mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, in resting CD4+ T cells, in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly, A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells, suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. In contrast, BCMA- or TACI-deficient mice have no major defect in B-cell development. While the function of BCMA is not defined, TACI has been shown to control B-cell homeostasis and T-cell-independent immune responses. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1, κ |
| Concentration | ≥ 1 mg/mL |
| Clone Name | H353-4A2 |
| Buffer | PBS, pH 7.2. Contains 0.05% proclin 300. |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
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Datasheet
Catalog Number
AN007780P-100mg-ELS
Name
Purified Anti-Human CD268 Antibody[H353-4A2]
Price(100 mg)
Pack Size