SKU: TA327188-OR
PSAP Rabbit Polyclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | ICC/IF, IHC, WB |
| Label | Unconjugated |
| Synonyms | GLBA; SAP1 |
| Gene ID | 5660 |
| Accession No. | NM_002778 |
| UniProt ID | P07602 |
| Background | The PSAP gene encodes prosaposin, a precursor of four small nonenzymatic glycoproteins termed sphingolipid activator proteins (SAPs) that assist in the lysosomal hydrolysis of sphingolipids. After proteolytic processing of the presaposin protein, these 4 released polypeptides are functional activators. Saposin A is encoded by residues 60 to 143 of PSAP, saposin B by 195 to 275, saposin C by 311 to 390, and saposin D by 405 to 487. They are four 12-14 kDa heatstable glycoproteins. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. Saposins A-D are required for the hydrolysis of certain sphingolipids by specific lysosomal hydrolases.Defects in PSAP are the cause of Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. This PSAP antibody (10801-1-AP) is expected to recognize both saposin A and B. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
TA327188-OR
Name
PSAP Rabbit Polyclonal Antibody
Price(0.1 mg)
Pack Size
0.1 mg