SKU: TA336445-OR
Presenilin 2 (PSEN2) Mouse Monoclonal Antibody [Clone ID: 198C679.2.]
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | WB |
| Label | Unconjugated |
| Synonyms | AD3L; AD4; CMD1V; PS2; STM2 |
| Gene ID | 5664 |
| Accession No. | NM_012486 |
| UniProt ID | P49810 |
| Background | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgM |
| Clone Name | 198C679.2. |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
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Datasheet
Catalog Number
TA336445-OR
Name
Presenilin 2 (PSEN2) Mouse Monoclonal Antibody [Clone ID: 198C679.2.]
Price(20 ml)
Pack Size
20 ml