SKU: TA334642-OR
Presenilin 1 (PSEN1) Rabbit Polyclonal Antibody
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Rat |
| Application | WB |
| Label | Unconjugated |
| Synonyms | AD3; FAD; PS-1; PS1; S182 |
| Gene ID | 5663 |
| Accession No. | NM_000021 |
| UniProt ID | P49768 |
| Background | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
TA334642-OR
Name
Presenilin 1 (PSEN1) Rabbit Polyclonal Antibody
Price(5000 ug)
Pack Size
5000 ug