SKU: A78729-100-EP
Presenilin 1 Polyclonal Antibody
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IHC-P, IF/ICC, ELISA |
| Label | Unconjugated |
| Synonyms | AD3; FAD; PS1; PS-1; S182; PSNL1; ACNINV3; Presenilin 1 |
| UniProt ID | P49768 |
| Immunogen | Recombinant protein (or fragment). Please contact BioCat for more information. |
| Background | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Buffer | Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
A78729-100-EP
Name
Presenilin 1 Polyclonal Antibody
Price(100 ul)
Pack Size
100 ul