SKU: E-AB-52172-20ul-ELS
PPM1D Polyclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Application | IHC |
| Label | Unconjugated |
| Synonyms | EC 3.1.3.16, p53 induced protein phosphatase 1, p53-induced protein phosphatase 1, PP2C delta, PP2C-delta, PP2CD, Ppm1d, PPM1D, Protein phosphatase 1D, protein phosphatase 1D magnesium-dependent delta isoform , Protein phosphatase 2C delta isoform, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium dependent 1 delta, Protein phosphatase magnesium-dependent 1 delta, Protein phosphatase Mg2+/Mn2+ dependent 1D, Protein phosphatase Wip1, Wild type p53 induced phosphatase 1, WIP 1, WIP1 |
| Accession No. | BC033893 |
| UniProt ID | O15297 |
| Immunogen | Fusion protein of human PPM1D |
| Background | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Concentration | 0.5 mg/mL |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
E-AB-52172-20ul-ELS
Name
PPM1D Polyclonal Antibody
Price(20 ul)
Pack Size