SKU: A83151-100-EP
Phospho-PLN-S16 Polyclonal Antibody
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, ELISA |
| Label | Unconjugated |
| Synonyms | PLB; CMD1P; CMH18; Phospho-PLN-S16 |
| UniProt ID | P26678 |
| Immunogen | Synthetic peptide. Please contact BioCat for more information. |
| Background | The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Buffer | Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
A83151-100-EP
Name
Phospho-PLN-S16 Polyclonal Antibody
Price(100 ul)
Pack Size
100 ul