SKU: A74181-100-EP
Phospho-MTOR (S2481) Recombinant Monoclonal Antibody [3H11]
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | ELISA, WB, IF |
| Label | Unconjugated |
| Synonyms | Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 |
| UniProt ID | P42345 |
| Immunogen | A synthesized peptide derived from human Phospho-MTOR (S2481) |
| Background | MTOR is a key serine/threonine protein kinase that centrally controls cellular functions like metabolism, growth, and survival in response to signals. It influences the phosphorylation of around 800 proteins directly or indirectly. It operates through two signaling complexes: mTORC1 and mTORC2. Activated mTORC1 enhances protein synthesis by phosphorylating factors in mRNA translation and ribosome production, including EIF4EBP1 which releases inhibition from translation initiation factor 4E. MTOR also activates RPS6KB1 and RPS6KB2, boosting protein synthesis via downstream targets like ribosomal protein S6, EIF4B, and the translation inhibitor PDCD4. It impacts pyrimidine biosynthesis and lipid synthesis. It regulates ribosome synthesis by phosphorylating and inhibiting MAF1, an RNA polymerase III repressor. MTORC1 interacts with autophagy, mitochondrial biogenesis, and growth factor signaling. In mTORC2, MTOR influences survival, cytoskeleton organization, and AKT1 activation at 'Ser-473', affecting cell growth. It also regulates osteoclastogenesis via CEBPB isoforms and contributes to various other cellular functions. |
| Primary / Secondary | Primary Antibody |
| Isotype | Rabbit IgG |
| Clone Name | 3H11 |
| Clonality | Monoclonal |
| Host | HEK293F Cell |
Catalog Number
A74181-100-EP
Name
Phospho-MTOR (S2481) Recombinant Monoclonal Antibody [3H11]
Price(10000 ul)
Pack Size
10000 ul