SKU: E-AB-F1159J-100Tests-ELS
PerCP/Cyanine5.5 Anti-Human CD197/CCR7 Antibody[G043H7]
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | FCM |
| Label | PerCP/Cyanine 5.5 |
| Synonyms | EBI1EVI1, CCR-7, CDw197, CMKBR7 |
| Gene ID | 1236 |
| UniProt ID | P32248 |
| Background | CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG2a, κ |
| Concentration | 5 μL/Test |
| Clone Name | G043H7 |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
PDF
Datasheet
Catalog Number
E-AB-F1159J-100Tests-ELS
Name
PerCP/Cyanine5.5 Anti-Human CD197/CCR7 Antibody[G043H7]
Price(100 tests)
Pack Size