SKU: E-AB-F1351G-100Tests-ELS
PE/Cyanine5 Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Mouse, Rat |
| Application | ICFCM |
| Label | PE/Cyanine 5 |
| Synonyms | IPEXJM2ScurfinZinc finger protein JM2, Forkhead box protein P3 |
| Gene ID | 20371 |
| UniProt ID | Q99JB6 |
| Background | FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. |
| Primary / Secondary | Primary Antibody |
| Isotype | Rat IgG2a, κ |
| Clone Name | FJK-16s |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Clonality | Monoclonal |
| Host | Rat |
Resources
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Datasheet
Catalog Number
E-AB-F1351G-100Tests-ELS
Name
PE/Cyanine5 Anti-Mouse/Rat Foxp3 Antibody[FJK-16s]
Price(10000 tests)
Pack Size