SKU: TA328900-OR
Nrxn1 Rabbit Polyclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | WB |
| Label | Unconjugated |
| Synonyms | DKFZp313P2036; FLJ35941; KIAA0578; OTTHUMP00000200525 |
| Gene ID | 60391 |
| Accession No. | NM_021767 |
| UniProt ID | Q63372 |
| Background | Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. NRXNS were identified as receptors for a-latrotoxin, a presynaptic toxin that triggers massive neurotransmitter release1. Neurexins are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each using an upstream promoter to produce the longer a-isoform (a-NRXNs) and a downstream promoter to generate a shorter �-isoform (�- NRXNs) .The a-isoforms and �-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains. NRXNs in neurons localize to the presynaptic membrane and bind trans-synaptically to postsynaptic adhesion molecules and receptors. Neurexins are expressed in all neurons, and are subject to extensive alternative splicing, generating >1,000 splice variants, some of which exhibit highly regulated developmental and spatial expression patterns. The extracellular domain of neurexin 1a (NRXN1a) is composed of three neurexin repeats (I, II, and III), which each contains the modules LNS-EGF-LNS. NRXN1a binds endogenous ligands including neuroligins, LRRTM family members, neurexophilin, a-dystroglycan, and GABA(A) receptors. NRXN1a gene mutations have been identified in neuropsychiatric diseases including Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD). |
| Primary / Secondary | Primary Antibody |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
TA328900-OR
Name
Nrxn1 Rabbit Polyclonal Antibody
Price(0.2 ml)
Pack Size
0.2 ml