SKU: A70181-100-EP
MICU1 Polyclonal Antibody, FITC Conjugated
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | ELISA |
| Label | FITC |
| Synonyms | Calcium uptake protein 1, mitochondrial, Atopy-related autoantigen CALC1, MICU1, CALC1 Publication |
| UniProt ID | Q9BPX6 |
| Immunogen | Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA) |
| Background | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, pH 7.4 |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
A70181-100-EP
Name
MICU1 Polyclonal Antibody, FITC Conjugated
Price(100 ul)
Pack Size