SKU: TA502978-OR
LIM Kinase 1 (LIMK1) Mouse Monoclonal Antibody [Clone ID: OTI8C8]
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | FC, IF, IHC, WB |
| Label | Unconjugated |
| Synonyms | LIMK; LIMK-1 |
| Gene ID | 3984 |
| Accession No. | NM_002314 |
| UniProt ID | P53667 |
| Background | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG2a |
| Clone Name | OTI8C8 |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
PDF
Datasheet
Catalog Number
TA502978-OR
Name
LIM Kinase 1 (LIMK1) Mouse Monoclonal Antibody [Clone ID: OTI8C8]
Price(0.1 ml)
Pack Size