SKU: TA336742-OR
IL1 beta (IL1B) Rabbit Polyclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | ICC/IF, IHC, WB |
| Label | Unconjugated |
| Synonyms | IL-1; IL1-BETA; IL1F2 |
| Gene ID | 3553 |
| Accession No. | NM_000576 |
| UniProt ID | P01584 |
| Background | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE).Two forms of interleukin-1, designated IL-1alpha and IL-1beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1alpha and IL-1beta bind to the same receptor and seem to elicit similar biological responses. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression and it induces B cell proliferation, maturation and immunoglobulin synthesis. NK cells require IL-1beta for production of the anti- pathogen IFN-gamma. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. |
| Primary / Secondary | Primary Antibody |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
TA336742-OR
Name
IL1 beta (IL1B) Rabbit Polyclonal Antibody
Price(0.1 mg)
Pack Size
0.1 mg