SKU: A80812-100-EP
Human Thioredoxin Reductase 1/TRXR1 Monoclonal Antibody [7P1J4]
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, ELISA |
| Label | Unconjugated |
| Synonyms | TR; TR1; TXNR; TRXR1; GRIM-12; Thioredoxin reductase 1 (TXNRD1 ) |
| UniProt ID | Q16881 |
| Immunogen | Recombinant protein (or fragment). Please contact BioCat for more information. |
| Background | The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clone Name | 7P1J4 |
| Buffer | Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3. |
| Clonality | Monoclonal |
| Host | Rabbit |
Catalog Number
A80812-100-EP
Name
Human Thioredoxin Reductase 1/TRXR1 Monoclonal Antibody [7P1J4]
Price(100 ul)
Pack Size
100 ul