SKU: A78844-100-EP
hnRNP E1/PCBP1 Monoclonal Antibody [7Y8C5]
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Application | WB, IF/ICC, ELISA |
| Label | Unconjugated |
| Synonyms | HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1; hnRNP E1/PCBP1 |
| UniProt ID | Q15365 |
| Immunogen | Synthetic peptide. Please contact BioCat for more information. |
| Background | This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clone Name | 7Y8C5 |
| Buffer | Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3. |
| Clonality | Monoclonal |
| Host | Rabbit |
Catalog Number
A78844-100-EP
Name
hnRNP E1/PCBP1 Monoclonal Antibody [7Y8C5]
Price(100 ul)
Pack Size
100 ul