SKU: E-AB-31399-120ul-ELS
FAK Polyclonal Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IHC-p, IF |
| Label | Unconjugated |
| Synonyms | FADK 1, FADK, FAK related non kinase polypeptide, FAK1, FAK1, Focal adhesion kinase 1, Focal adhesion Kinase, Focal adhesion kinase isoform FAK Del33, Focal adhesion kinase related nonkinase, FRNK, p125FAK, pp125FAK, PPP1R71, Protein phosphatase 1 regulatory subunit 71, Protein tyrosine kinase 2, Protein-tyrosine kinase 2, Ptk2, PTK2 protein tyrosine kinase 2 |
| UniProt ID | Q05397 |
| Immunogen | Synthesized peptide derived from human FAK around the non-phosphorylation site of Tyr397. |
| Background | Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4 |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
E-AB-31399-120ul-ELS
Name
FAK Polyclonal Antibody
Price(120 ul)
Pack Size