SKU: E-AB-F1238M1-50Tests-ELS
Elab Fluor®700 Anti-Mouse Foxp3 Antibody[3G3]
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Mouse |
| Application | FCM |
| Label | Elab Fluor®700 |
| Synonyms | Forkhead box protein P3, Foxp3, IPEX, JM2 |
| Gene ID | 50943,20371,317382 |
| UniProt ID | Q99JB6 |
| Background | Foxp3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of Foxp3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. Foxp3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of Foxp3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of Foxp3 have been reported: one (Foxp3) corresponding to the canonical full-length sequence; the other (Foxp3 δ2) lacking exon 2. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1, κ |
| Clone Name | 3G3 |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
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Datasheet
Catalog Number
E-AB-F1238M1-50Tests-ELS
Name
Elab Fluor�700 Anti-Mouse Foxp3 Antibody[3G3]
Price(5000 tests)
Pack Size