SKU: A77676-100-EP
Doublecortin Monoclonal Antibody
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Mouse, Rat |
| Application | WB, ELISA |
| Label | Unconjugated |
| Synonyms | DC; DBCN; LISX; SCLH; XLIS; Doublecortin |
| UniProt ID | O43602 |
| Immunogen | Synthetic peptide. Please contact BioCat for more information. |
| Background | This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Clone Name | 6H1B3 |
| Buffer | Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3. |
| Clonality | Monoclonal |
| Host | Rabbit |
Catalog Number
A77676-100-EP
Name
Doublecortin Monoclonal Antibody
Price(100 ul)
Pack Size
100 ul