SKU: E-AB-91147-120ul-ELS
CRTC1 Polyclonal Antibody
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Mouse,Rat |
| Application | WB |
| Label | Unconjugated |
| Synonyms | CRTC1,MECT1,TORC-1,TORC1,WAMTP1 |
| Gene ID | 23373 |
| UniProt ID | Q6UUV9 |
| Immunogen | Recombinant fusion protein of human CRTC1 |
| Background | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
E-AB-91147-120ul-ELS
Name
CRTC1 Polyclonal Antibody
Price(120 ul)
Pack Size