SKU: E-AB-18608-120ul-ELS
CEP57 Polyclonal Antibody
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | WB |
| Label | Unconjugated |
| Synonyms | Centrosomal protein 57kDa, Centrosomal protein of 57 kDa, Cep57, Cep57 protein, CEP57, FGF2 interacting protein, FGF2-interacting protein, KIAA0092, MVA2, PIG8, Proliferation inducing protein 8, Testis specific protein 57, Testis-specific protein 57, Translokin, TSP57 |
| Accession No. | BC039711 |
| UniProt ID | Q86XR8 |
| Immunogen | Full length fusion protein |
| Background | This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Concentration | 0.42 mg/mL |
| Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
E-AB-18608-120ul-ELS
Name
CEP57 Polyclonal Antibody
Price(12000 ul)
Pack Size