SKU: E-AB-60411-120ul-ELS
CD59 Polyclonal Antibody
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human,Mouse,Rat |
| Application | IHC |
| Label | Unconjugated |
| Synonyms | 16.3A5,1F5,CD59,EJ16,EJ30,EL32,G344,HRF-20,HRF20,MAC-IP,MACIF,MEM43,MIC11,MIN1,MIN2,MIN3,MIRL,MSK21,p18-20 |
| Gene ID | 966 |
| UniProt ID | P13987 |
| Immunogen | Recombinant protein of human CD59 |
| Background | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Clonality | Polyclonal |
| Host | Rabbit |
Resources
PDF
Datasheet
Catalog Number
E-AB-60411-120ul-ELS
Name
CD59 Polyclonal Antibody
Price(120 ul)
Pack Size