SKU: A50115-100-EP
CD46 Polyclonal Antibody, FITC Conjugated
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | ELISA |
| Label | FITC |
| Synonyms | TLX, Trophoblast leukocyte common antigen, CD46, MCP, MIC10 |
| UniProt ID | P15529 |
| Immunogen | Recombinant Human Membrane cofactor protein (164-325AA) |
| Background | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4 |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
A50115-100-EP
Name
CD46 Polyclonal Antibody, FITC Conjugated
Price(100 ul)
Pack Size