SKU: AN200193P-100ul-ELS
CCNE1/Cyclin-E1 Monoclonal Antibody
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | IHC-P |
| Label | Unconjugated |
| Synonyms | G1/S-specific cyclin-E, pCCNE, cyclin E, CCNE1, CCNE, pCCNE1, cyclin E1, cyclin E variant ex5del, cyclin E variant ex7del, Cyclin Es, Cyclin Et, CyclinE, G1/S specific cyclin E, G1/S-specific cyclin-E1 |
| UniProt ID | P24864 |
| Immunogen | Recombinant Human CCNE1/Cyclin-E1 protein |
| Background | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG1 |
| Concentration | 1 mg/mL |
| Clone Name | 11D10 |
| Buffer | 0.2 μm filtered solution in PBS |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
PDF
Datasheet
Catalog Number
AN200193P-100ul-ELS
Name
CCNE1/Cyclin-E1 Monoclonal Antibody
Price(10000 ul)
Pack Size
10000 ul