SKU: TA336776-OR
Calreticulin (CALR) Mouse Monoclonal Antibody [Clone ID: 1G6A7]
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Application | ELISA, FC, ICC/IF, IHC, WB |
| Label | Unconjugated |
| Synonyms | cC1qR; CRT; HEL-S-99n; RO; SSA |
| Gene ID | 811 |
| Accession No. | NM_004343 |
| UniProt ID | P27797 |
| Background | Calreticulin is the major calcium binding protein found in smooth muscle sarcoplasmic reticulum (SR) and non-muscle endoplasmic reticulum (ER) membranes. This protein was originally identified in SR membranes and plays a minor role in calcium storage in skeletal and cardiac muscle SR. Calreticulin is also known as calregulin, CRP55, CaBP3, calsequestrin-like protein and Ro/SS-A antigen. Calreticulin binds calcium with low affinity and high capacity, however, it also exhibits a single high affinity binding site. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C-terminus of calreticulin and other resident ER proteins including glucose regulated protein 78 (GRP78), GRP94 and protein disulfide isomerase (PDI). This sequence is responsible for the retention of newly synthesized proteins within the ER lumen. This retention is reported to be mediated by a KDEL receptor. Recent reports indicate that calreticulin can act as a modulator of the regulation of gene transcription by nuclear hormone receptors and may also act as a molecular chaperone. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG2a |
| Clone Name | 1G6A7 |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
PDF
Datasheet
Catalog Number
TA336776-OR
Name
Calreticulin (CALR) Mouse Monoclonal Antibody [Clone ID: 1G6A7]
Price(10 ml)
Pack Size
10 ml