SKU: E-AB-F1133B-25ug-ELS
Biotin Anti-Human CD274/PD-L1 Antibody[29E.2A3]
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | FCM |
| Label | Biotin |
| Synonyms | B7H1PD-L1PDCD1L1PDCD1LG1PDL1, B7 homolog 1, B7-H, B7-H1, Programmed cell death ligand 1 |
| Gene ID | 29126 |
| UniProt ID | Q9NZQ7 |
| Background | CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG2b, κ |
| Concentration | 0.5 mg/mL |
| Clone Name | 29E.2A3 |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Clonality | Monoclonal |
| Host | Mouse |
Resources
PDF
Datasheet
Catalog Number
E-AB-F1133B-25ug-ELS
Name
Biotin Anti-Human CD274/PD-L1 Antibody[29E.2A3]
Price(25 ug)
Pack Size