SKU: A69278-050-EP
BHLHE41 Polyclonal Antibody, Biotin Conjugated
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | ELISA |
| Label | Biotin |
| Synonyms | Class E basic helix-loop-helix protein 41, bHLHe41, Class B basic helix-loop-helix protein 3, bHLHb3, Differentially expressed in chondrocytes protein 2, hDEC2, Enhancer-of-split and hairy-related protein 1, SHARP-1, BHLHE41, BHLHB3, DEC2, SHARP1 |
| UniProt ID | Q9C0J9 |
| Immunogen | Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA) |
| Background | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Buffer | 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, pH 7.4 |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
A69278-050-EP
Name
BHLHE41 Polyclonal Antibody, Biotin Conjugated
Price(50 ul)
Pack Size