axoCells Human iPSC-Derived Sensory Neurons (newborn male donor)

Product Description

axoCells Human iPSC-Derived Sensory Neurons for pain and sensation research. Sensory neurons made from iPSCs which were generated from a newborn male donor's cord blood. 

• Assay-ready in just 21 days with our Maturation Maximizer media supplement
• Designed for advanced in vitro model formats including co-culture, microfluidics devices and organ-on-chip platforms
• Manufactured in our ISO 9001-accredited production facility with excellent ISSCR Standards compliance 

Axol Human iPSC-Sensory Neuron Progenitors are derived from integration-free iPSCs and have been differentiated to neurons using small molecules. We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium and coating reagents to promote the viability and maturation of sensory neurons for endpoint assays on glass or plastic.

Axol iPSC-derived sensory neurons express several voltage-gated sodium ion channels and transient receptor potential (TRP) ion channels that play a key role in nociception. These include sodium ion channels Nav1.7 and the DRG-specific, TTX-resistant channels, Nav1.8 and Nav1.9 as well as the temperature-sensitive, TRPV1 and TRPM8, and TRPA1, a sensor of pungency, bitterness and cold. iPSC-derived sensory neurons have functional relevance across multiple assays including capsaicin and menthol treatment, thermoception and neurite outgrowth with paclitaxel for a model of chemotherapy-induced peripheral neuropathy

Axol iPSC-Derived Sensory Neuron Progenitors are available in large batch sizes for reliable and consistent results in high-throughput screening assays. The cells are also suitable for investigating disorders of the peripheral nervous system and chronic pain as well as drug targets for pain relief.