SKU: 188-11115-2-RB
Anti-VEGI / TL1A Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | FACS, WB, IHC, IF |
| Label | Unconjugated |
| Gene ID | 9966 |
| Accession No. | O95150 |
| Immunogen | A full length human recombinant protein was used as the immunogen for this TL1A antibody. |
| Background | TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1, kappa |
| Concentration | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Host | Mouse |
Catalog Number
188-11115-2-RB
Name
Anti-VEGI / TL1A Antibody
Price(100 ug)
Pack Size