SKU: 102-20107-RB
Anti-ULK3 (C-term) Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | WB |
| Label | Unconjugated |
| Gene ID | 25989 |
| Accession No. | Q6PHR2 |
| Immunogen | This ULK3 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the C-terminal region of human ULK3. |
| Background | Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG1,k |
| Clone Name | 1404CT148.89.25 |
| Clonality | Monoclonal |
| Host | Mouse |
Catalog Number
102-20107-RB
Name
Anti-ULK3 (C-term) Antibody
Price(400 ul)
Pack Size
400 ul