SKU: 188-11579-2-RB
Anti-Thyroglobulin Antibody
In Stock
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | FC, IHC (Prediluted format) |
| Label | Unconjugated |
| Gene ID | 7038 |
| Accession No. | P01266 |
| Immunogen | Human thyroid follicular cells were used as the immunogen for this anti-Thyroglobulin antibody. |
| Background | Thyroglobulin is a 66kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1, kappa |
| Concentration | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Host | Mouse |
Catalog Number
188-11579-2-RB
Name
Anti-Thyroglobulin Antibody
Price(10000 ug)
Pack Size