SKU: RB-02-0029-200-RB
Anti-SMAC Antibody
RT
Specifications
| Specification | Details |
|---|---|
| Application | ELISA, Western Blot |
| Label | Unconjugated |
| Immunogen | The immunogen was a synthetic peptide (SMAC). This antibody was produced from a rabbit immunized with this peptide conjugated with KLH. The IgG fraction was purified from rabbit serum by Protein G affinity chromatography. |
| Background | Second mitochondria-derived activator of caspases, SMAC is a mitochondrial protein that promotes cytochrome-c dependent activation by eliminating the inhibition via IAP - a protein that negatively regulates apoptosis or programmed cell death. Smac is normally a mitochondrial protein but is found in the cytosol when a cell is primed for apoptosis by the final execution step of caspase activation. Smac is the second protein in the apoptosis link, along with cytochrome c, that promotes apoptosis by activating caspases. SMAC is an inhibitor of apoptosis protein (IAP)-binding protein. This mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. |
| Primary / Secondary | Primary Antibody |
| Clonality | Polyclonal |
Catalog Number
RB-02-0029-200-RB
Name
Anti-SMAC Antibody
Price(200 ug)
Pack Size