SKU: 144-60442-100-RB
Anti-PMS2 Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | WB,IF,IP |
| Label | Unconjugated |
| Gene ID | 5395 |
| Accession No. | P54278 |
| Background | The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. |
| Primary / Secondary | Primary Antibody |
| Isotype | IgG |
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
144-60442-100-RB
Name
Anti-PMS2 Antibody
Price(100 ul)
Pack Size