SKU: 102-24346-RB
Anti-Mouse Smarcd3 (Center) Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse |
| Application | WB |
| Label | Unconjugated |
| Gene ID | 66993 |
| Accession No. | Q6P9Z1 |
| Immunogen | This Mouse Smarcd3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 158-193 amino acids from the Central region of Mouse Smarcd3. |
| Background | Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription (By similarity). Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF1/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| Primary / Secondary | Primary Antibody |
| Isotype | Rabbit Ig |
| Clone Name | RB51970 |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
102-24346-RB
Name
Anti-Mouse Smarcd3 (Center) Antibody
Price(400 ul)
Pack Size
400 ul