SKU: 188-11462-1-RB
Anti-MAML3 Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | FACS, IF, IHC |
| Label | Unconjugated |
| Gene ID | 55534 |
| Accession No. | Q96JK9 |
| Immunogen | A human full length recombinant protein was used as the immunogen for this MAML3 antibody. |
| Background | Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1 |
| Concentration | 0.2 mg/ml in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Host | Mouse |
Catalog Number
188-11462-1-RB
Name
Anti-MAML3 Antibody
Price(20 ug)
Pack Size