SKU: 188-10436-SAF-RB
Anti-HLA-DR Antibody (MHC II), Sodium Azide Free
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Monkey |
| Application | Flow Cytometry, Immunofluorescence |
| Label | Unconjugated |
| Gene ID | 3122 |
| Accession No. | P01903 |
| Immunogen | Spleen cells from a patient with hairy cell leukemia were used as the immunogen for the HLA-DR antibody. |
| Background | mAb IPO-1 defines the antigen, which appears on B cell progenitors following HLA-DR and preceding CD1, CD19, CD22, CD37 and cym. It is expressed on resting B cells and than reappears and persists in cytoplasm and on cell surface until cytoplasmic Ig appears. It is a useful antibody for diagnostics of neoplasms of B cell origins. It reacts with human B cell lines Daudi, Raji, Namalva, EB-3, RPMI-8226 (5% of cells). The mAb does not label T cell lines, blood granulocytes, thymocytes or bone marrow stromal fibroblasts. No significant changes are detected after PHA or ConA stimulation while LPS and PWM stimulated cultures after 18-48h show decreased number of antigen-positive cells but in final terms of cultivation antigen is expressed again. This mAb labels B cell leukemias and some lymphomas. Hairy cell leukemia strongly reacts and 7% of B cell CLL and some B-NHL were also positive. IPO-1 reacts with AMML cells and in a majority of Hodgkin's disease cases a significant percentage of affected lymph node cells were detected. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG3, kappa |
| Concentration | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Host | Mouse |
Catalog Number
188-10436-SAF-RB
Name
Anti-HLA-DR Antibody (MHC II), Sodium Azide Free
Price(100 ug)
Pack Size
100 ug