SKU: 188-10391-SAF-RB

Anti-Glypican-3 Antibody, Sodium Azide Free

In Stock Blue Ice

Specifications

Specification	Details
Species Reactivity	Human, Rat
Application	FC, IF, IHC (Prediluted format)
Label	Unconjugated
Gene ID	2719
Accession No.	P51654
Immunogen	Recombinant full-length human GPC3 protein was used as the immunogen for the Glypican-3 antibody.
Background	Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 1% in follicular carcinoma and 7% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.
Primary / Secondary	Primary Antibody
Isotype	Mouse IgG1, kappa
Concentration	1 mg/ml in 1X PBS, BSA free, sodium azide free
Host	Mouse

Catalog Number

188-10391-SAF-RB

Name

Anti-Glypican-3 Antibody, Sodium Azide Free

Price(10000 ug)

10000 ug

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