SKU: 188-11091-1-RB
Anti-E-Cadherin / CDH1 Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | FC, IF, WB, IHC |
| Label | Unconjugated |
| Gene ID | 999 |
| Accession No. | P12830 |
| Immunogen | A recombinant human protein was used as the immunogen for the E-Cadherin antibody. |
| Background | Recognizes a protein of 8-12kDa, identified as E-cadherin/CDH1. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as b-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p12 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1, kappa |
| Concentration | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Host | Mouse |
Catalog Number
188-11091-1-RB
Name
Anti-E-Cadherin / CDH1 Antibody
Price(20 ug)
Pack Size