SKU: 102-23745-RB
Anti-DCLK2 (N-term) Antibody
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | WB |
| Label | Unconjugated |
| Gene ID | 166614 |
| Accession No. | Q8N568, NP_001035351.3 |
| Immunogen | This DCLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the N-terminal region of human DCLK2. |
| Background | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. |
| Primary / Secondary | Primary Antibody |
| Isotype | Rabbit Ig |
| Clone Name | RB41922 |
| Clonality | Polyclonal |
| Host | Rabbit |
Catalog Number
102-23745-RB
Name
Anti-DCLK2 (N-term) Antibody
Price(400 ul)
Pack Size
400 ul