SKU: 188-10965-SAF-RB
Anti-CLIP Antibody, Sodium Azide Free
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | FC, IF, IHC (Prediluted format) |
| Label | Unconjugated |
| Gene ID | 972 |
| Accession No. | P04233 |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the CLIP antibody. |
| Background | Recognizes proteins of 33, 35 and 41kDa, which are identified as various isoforms of CD74/CLIP. Its epitope is localized in the extracellular domain of CD74. CD74/CLIP is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. The molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74/CLIP is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, and dendritic cells and by various types of carcinomas. It is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74/CLIP stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas and has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+). |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1, kappa |
| Concentration | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Host | Mouse |
Catalog Number
188-10965-SAF-RB
Name
Anti-CLIP Antibody, Sodium Azide Free
Price(100 ug)
Pack Size
100 ug