SKU: 188-11225-2-RB
Anti-CD8 Antibody (alpha chain)
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Application | FC, IF, IHC |
| Label | Unconjugated |
| Gene ID | 925 |
| Accession No. | P01732 |
| Immunogen | Recombinant full-length human CD8a protein was used as immunogen for this recombinant CD8 antibody. |
| Background | CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. |
| Primary / Secondary | Primary Antibody |
| Isotype | Rabbit IgG, k |
| Concentration | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Host | Rabbit |
Catalog Number
188-11225-2-RB
Name
Anti-CD8 Antibody (alpha chain)
Price(100 ug)
Pack Size