SKU: 188-11017-SAF-RB
Anti-Beta Catenin Antibody, Sodium Azide Free
Blue Ice
Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IF, IHC, FC |
| Label | Unconjugated |
| Gene ID | 1499 |
| Accession No. | P35222 |
| Immunogen | A partial human recombinant protein was used as the immunogen for the Beta Catenin antibody. |
| Background | Beta-Catenin associates with the cytoplasmic portion of E-Cadherin, which is necessary for the function of E-Cadherin as an adhesion molecule. In normal tissues, beta-Catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-Catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immunostaining of beta-Catenin and E-Cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. |
| Primary / Secondary | Primary Antibody |
| Isotype | Mouse IgG1, kappa |
| Concentration | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Host | Mouse |
Catalog Number
188-11017-SAF-RB
Name
Anti-Beta Catenin Antibody, Sodium Azide Free
Price(100 ug)
Pack Size
100 ug