Annexin V-Biotin Reagent

Elabscience® Annexin V-Biotin is developed to identify apoptotic and necrotic cells. Annexin V is a member of the annexin family, which binds to phosphatidylserine (PS) in a calcium-dependent manner. It binds specifically to the PS on the outer leaflet apoptotic cell membrane and can be detected with flow cytometry or fluorescence microscopy after conjugated with fluorescence. Cells at different apoptotic stages can be distinguished by using Annexin V and membrane impermeable DNA dyes like Propidium Iodide (PI), 7-AAD and DAPI.