SU-11752
Specifications | |
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CAS Number: | 688036-19-3 |
Formula: | C26H27N3O5S |
Molecular Weight: | 493,57 |
Description
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.
Price
1.822,00 €